Differential immunotoxicity of histone deacetylase inhibitors on malignant and naïve hepatocytesReport as inadecuate




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Abstract : Histone deacetylases HD represent a novel target in cancer treatment, in particular of scattered small tumours such as the hepatocellular carcinoma HCC. However, only few studies address the toxicological impact of HD Inhibitors HDIs on malignantly transformed cells versus primary hepatocytes. We examined whether and how different classes of HDIs sensitise the human HCC cell line HepG2, primary healthy murine and human liver cells towards the death receptor agonists TNFα and CD95L.

Keywords : ActD CBHA HDAC HDI M344 VPA TNF TRAIL CD95L cFLIP XIAP Hepatocellular carcinoma Adverse side effect Primary hepatocytes





Author: Markus Weiller Timo Weilandl Georg Dünstl Ulrike Sack Gerald Künstle Albrecht Wendel -

Source: https://hal.archives-ouvertes.fr/



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