The development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine CXCL8 interleukin-8Report as inadecuate




The development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine CXCL8 interleukin-8 - Download this document for free, or read online. Document in PDF available to download.

Arthritis Research and Therapy

, 3:65

First Online: 09 November 2000Received: 18 July 2000Revised: 22 September 2000Accepted: 12 October 2000

Abstract

Paired synovial tissue samples were obtained from both clinically uninvolved CU and clinically involved CI knee joints of eight rheumatoid arthritis RA patients. In addition, biopsies were taken from five control subjects. We observed the expression of the chemokines CXCL8, CXCL9, CXCL10, CCL2 and CCL4 in CI and CU joints of RA patients. In particular, CXCL8 protein levels were specifically increased in CI joints compared with CU joints, which was confirmed by immunohistochemistry and in situ hybridization.

Keywordsarthritis chemokines CXCL8 patients synovium  Download fulltext PDF



Author: Maarten C Kraan - Dhavalkumar D Patel - Jasper J Haringman - Malcolm D Smith - Helen Weedon - Michael J Ahern - Ferdina

Source: https://link.springer.com/







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