Effects of 900 MHz radiofrequency on corticosterone, emotional memory and neuroinflammation in middle-aged ratsReport as inadecuate




Effects of 900 MHz radiofrequency on corticosterone, emotional memory and neuroinflammation in middle-aged rats - Download this document for free, or read online. Document in PDF available to download.

* Corresponding author 1 INERIS - Institut National de l-Environnement Industriel et des Risques 2 Laboratoire PériTox - INERIS

Abstract : The widespread use of mobile phones raises the question of the effects of electromagnetic fields EMF, 900 MHz on the brain. Previous studies reported increased levels of the glial fibrillary acidic protein GFAP in the rat-s brain after a single exposure to 900 MHz global system for mobile GSM signal, suggesting a potential inflammatory process. While this result was obtained in adult rats, no data is currently available in older animals. Since the transition from middle-age to senescence is highly dependent on environment and lifestyle, we studied the reactivity of middle-aged brains to EMF exposure. We assessed the effects of a single 15 min GSM exposure 900 MHz ; specific absorption rate SAR=6 W-kg on GFAP expression in young adults 6 week-old and middle-aged rats 12 month-old. Brain interleukin IL-1ß and IL-6, plasmatic levels of corticosterone CORT, and emotional memory were also assessed. Our data indicated that, in contrast to previously published work, acute GSM exposure did not induce astrocyte activation. Our results showed an IL-1ß increase in the olfactory bulb and enhanced contextual emotional memory in GSM-exposed middle-aged rats, and increased plasmatic levels of CORT in GSMexposed young adults. Altogether, our data showed an age dependency of reactivity to GSM exposure in neuro-immunity, stress and behavioral parameters. Reproducing these effects and studying their mechanisms may allow a better understanding of mobile phone EMF effects on neurobiological parameters.

Keywords : MIDDLE-AGE RADIOFREQUENCY INTERLEUKIN-1SS INTERLEUKIN-6 CORTICOSTERONE FEAR CONDITIONING





Author: Marc Bouji - Anthony Lecomte - Yannick Hode - René De Seze - Anne-Sophie Villegier -

Source: https://hal.archives-ouvertes.fr/



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