Association of aminothiols with the clinical outcome in hemodialysis patients: comparison of chromatography and immunoassay for homocysteine determination: aminothiols as predictive factors of hemodialysis outcomeReport as inadecuate




Association of aminothiols with the clinical outcome in hemodialysis patients: comparison of chromatography and immunoassay for homocysteine determination: aminothiols as predictive factors of hemodialysis outcome - Download this document for free, or read online. Document in PDF available to download.

1 Département de biochimie Montpellier 2 Pathologies du système nerveux : recherche épidémiologique et clinique 3 Département de nephrologie 4 CHLM - Centre hémodialyse Languedoc Méditerranée 5 Epidémiologie, santé publique et développement

Abstract : Background: Controversial results about hyperhomocysteinemia and cardiovascular CV risk in hemodialysis HD could be due in part to the methodology used for homocysteine Hcy determination.
Objective: To compare the influence of the method used for Hcy determination chromatography or immunoassay, in regard to the association of Hcy with CV mortality rate in HD patients in a 3 year prospective study.
Methods: One hundred sixty-two patients undergoing HD were included in a cohort study.
Baseline Hcy levels were measured by high performance liquid chromatography HPLC and fluorescence polarization immunoassay FPIA.
Cysteine and cysteinylglycine were determined simultaneously to Hcy measure by HPLC.
Results: Hcy levels obtained with both methods were highly correlated r2=0.927, p



Author: Stéphanie Badiou - Isabelle Jaussent - Nathalie Terrier - Estelle Naudin - Hélène Leray-Moragues - François Maurice - Anne-Ma

Source: https://hal.archives-ouvertes.fr/



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