Serum resistin is associated with C-reactive protein and LDL- cholesterol in type 2 diabetes and coronary artery disease in a Saudi populationReport as inadecuate




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Cardiovascular Diabetology

, 4:10

First Online: 05 July 2005Received: 18 February 2005Accepted: 05 July 2005

Abstract

AimsResistin is an adipocyte-derived factor implicated in obesity-associated type 2 diabetes T2DM. This study examines the association between human serum resistin, T2DM and coronary heart disease.

MethodsOne hundred and fourteen Saudi Arabian patients male: female ratio 46:68; age 51.4 mean ± SD11.7 years; median and range: 45.59 11.7 years and BMI: 27.1 mean ± SD 8.1 Kgm median and range: 30.3 6.3 were studied. Serum resistin and C-reactive protein CRP, a marker of inflammation CRP levels, were measured in all subjects. 35 patients had type 2 diabetes mellitus T2DM; 22 patients had coronary heart disease CHD.

ResultsSerum resistin levels were 1.2-fold higher in type 2 diabetes and 1.3-fold higher in CHD than in controls p = 0.01. In addition, CRP was significantly increased in both T2DM and CHD patients p = 0.007 and p = 0.002 respectively. The use of regression analysis also determined that serum resistin correlated with CRP levels p = 0.04, R 0.045.

ConclusionThe findings from this study further implicate resistin as a circulating protein associated with T2DM and CHD. In addition this study also demonstrates an association between resistin and CRP, a marker of inflammation in type 2 diabetic patients.

Keywordstype 2 diabetes Coronary Artery disease resistin C-reactive protein Electronic supplementary materialThe online version of this article doi:10.1186-1475-2840-4-10 contains supplementary material, which is available to authorized users.

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Author: N Al-Daghri - R Chetty - PG McTernan - K Al-Rubean - O Al-Attas - AF Jones - S Kumar

Source: https://link.springer.com/article/10.1186/1475-2840-4-10







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