In vivo mouse spinal cord imaging using echo-planar imaging at 11.75 TReport as inadecuate




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Magnetic Resonance Materials in Physics, Biology and Medicine

, 20:169

First Online: 28 July 2007Received: 13 April 2007Revised: 31 May 2007Accepted: 29 June 2007

Abstract

Object To evaluate the feasibility of mouse spinal cord MR imaging using echo-planar imaging EPI.

Materials and methods Optimized multi-shot spin-echo-EPI sequences were compared to conventional spin-echo c-SE at 11.75 T and used for high-spatially resolved acquisitions and relaxation-time measurements.

Results Good quality images were obtained, with clear delineation of gray and white matter. Acquisition-time gain factor was up to 6 vs. c-SE and resolution up to 74 × 94 μm was achieved. T1 and T2 relaxation times were reliably measured.

Conclusion High-temporally and spatially resolved mouse spinal cord EPI imaging is feasible. This technique should greatly benefit to long acquisition-time experiments diffusion imaging and imaging of rapidly-evolving pathologies.

KeywordsMRI Echo planar imaging EPI Spinal cord Mouse High-field V. Callot and G. Duhamel equally contributed to this work.

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Author: Virginie Callot - Guillaume Duhamel - Patrick J. Cozzone

Source: https://link.springer.com/







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