Interaction between Calpain 5, Peroxisome proliferator-activated receptor-gamma and Peroxisome proliferator-activated receptor-delta genes: a polygenic approach to obesityReport as inadecuate




Interaction between Calpain 5, Peroxisome proliferator-activated receptor-gamma and Peroxisome proliferator-activated receptor-delta genes: a polygenic approach to obesity - Download this document for free, or read online. Document in PDF available to download.

Cardiovascular Diabetology

, 7:23

First Online: 25 July 2008Received: 12 May 2008Accepted: 25 July 2008

Abstract

ContextObesity is a multifactorial disorder, that is, a disease determined by the combined effect of genes and environment. In this context, polygenic approaches are needed.

ObjectiveTo investigate the possibility of the existence of a crosstalk between the CALPAIN 10 homologue CALPAIN 5 and nuclear receptors of the peroxisome proliferator-activated receptors family.

DesignCross-sectional, genetic association study and gene-gene interaction analysis.

SubjectsThe study sample comprise 1953 individuals, 725 obese defined as body mass index ≥ 30 and 1228 non obese subjects.

ResultsIn the monogenic analysis, only the peroxisome proliferator-activated receptor delta PPARD gene was associated with obesity OR = 1.43 1.04–1.97, p = 0.027. In addition, we have found a significant interaction between CAPN5 and PPARD genes p = 0.038 that reduces the risk for obesity in a 55%.

ConclusionOur results suggest that CAPN5 and PPARD gene products may also interact in vivo.

Electronic supplementary materialThe online version of this article doi:10.1186-1475-2840-7-23 contains supplementary material, which is available to authorized users.

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Author: María E Sáez - Antonio Grilo - Francisco J Morón - Luis Manzano - María T Martínez-Larrad - Antonio González-Pérez

Source: https://link.springer.com/article/10.1186/1475-2840-7-23







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