Comparison of research case definitions for carpal tunnel syndrome.: Research case definitions of carpal tunnel syndromeReport as inadecuate




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* Corresponding author 1 CESP - Centre de recherche en épidémiologie et santé des populations 2 Division of General Medical Sciences 3 Department of Environmental Health Sciences

Abstract : OBJECTIVE: The aim of this study was to assess agreement between different case definitions of carpal tunnel syndrome CTS for epidemiological studies. METHODS: We performed a literature search for papers suggesting case definitions for use in epidemiological studies of CTS. Using data elements based on symptom questionnaires, hand diagrams, physical examinations, and nerve conduction studies collected from 1107 newly-hired workers, each subject in the study was classified according to each of the case definitions selected from the literature. We compared each case definition to every other case definition, using the Kappa statistic to measure pair-wise agreement on whether each subject met the case definition. RESULTS: We found six unique papers in a 20-year period suggesting a case definition of CTS for use in population-based studies. We extracted seven case definitions. Definitions included different parameters: i symptoms only, ii symptoms and physical examination, iii symptoms and either physical examination or median nerve conduction study, and iv symptoms and nerve conduction study. When applied to our study population, the prevalence of CTS using different case definitions ranged from 2.5-11.0%. The percentage of misclassification was between 1-10%, with generally acceptable levels of agreement kappa values ranged from 0.30-0.85. CONCLUSIONS: Different case definitions resulted in widely varying prevalences of CTS. Agreement between case definitions was generally good, particularly between those that required very specific symptoms or the combination of symptoms and physical examination or nerve conduction. The agreement observed between different case definitions suggests that the results can be compared across different research studies of risk factors for CTS.

Keywords : median neuropathy population study nerve conduction studies screening





Author: Alexis Descatha - Ann-Marie Dale - Alfred Franzblau - Justin Coomes - Bradley Evanoff -

Source: https://hal.archives-ouvertes.fr/



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