A history of late and very late stent thrombosis is not associated with increased activation of the contact system, a case control studyReport as inadecuate




A history of late and very late stent thrombosis is not associated with increased activation of the contact system, a case control study - Download this document for free, or read online. Document in PDF available to download.

Thrombosis Journal

, 8:6

First Online: 15 April 2010Received: 14 September 2009Accepted: 15 April 2010

Abstract

BackgroundThe pathophysiological pathways resulting in Late Stent Thrombosis LST remain uncertain. Findings from animal studies indicate a role of the intrinsic coagulation pathway in arterial thrombus formation, while clinical studies support an association with ischemic cardiovascular disease. It is currently unknown whether differences in the state of the contact system might contribute to the risk of LST or Very Late Stent Thrombosis VLST. We assessed the relation between levels of several components involved in the contact system and a history of LST and VLST, termed VLST in a cohort of 20 patients as compared to a matched control group treated with PCI.

Methods and ResultsActivated factor XII FXIIa, FXII zymogen FXII, FXIIa-C1-esterase inhibitor C1-inhibitor, Kallikrein-C1-inhibitor, FXIa-C1-inhibitor and FXIa-α1-antitrypsin AT-inhibitor complexes were measured by Enzyme-linked immunosorbent assy ELISA methodology.

Cases and controls showed similar distributions in sex, age, baseline medications and stent type. Patients with a history of VLST had a significantly greater stent burden and a higher number of previous myocardial infarctions than the control patients.

There were no significant between-group differences in the plasma levels of the components of the contact system.

ConclusionIn a cohort of patients with a history of VLST, we did not observe differences in the activation state of the intrinsic coagulation system as compared to patients with a history of percutaneous coronary intervention without stent thrombosis.

Download fulltext PDF



Author: Volker Pönitz - José W Govers-Riemslag - Hugo ten Cate - Rene van Oerle - Trygve Brügger-Andersen - Heidi Grundt - Patry

Source: https://link.springer.com/article/10.1186/1477-9560-8-6







Related documents