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Current Heart Failure Reports

, Volume 7, Issue 2, pp 83–90

First Online: 21 April 2010


Epigenetics studies inheritable changes of genes and gene expression that do not concern DNA nucleotide variation. Such modifications include DNA methylation, several forms of histone modification, and microRNAs. From recent studies, we know not only that genetic changes account for heritable phenotypic variation, but that epigenetic changes also play an important role in the variation of predisposition to disease and to drug response. In this review, we discuss recent evidence of epigenetic changes that play an important role in the development of cardiac hypertrophy and heart failure and may dictate response to therapy.

KeywordsDNA methylation Epigenetics Heart failure Histone modification MicroRNA Pharmacoepigenetics  Download fulltext PDF

Author: Irene Mateo Leach - Pim van der Harst - Rudolf A. de Boer


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