GCKR gene functional variants in type 2 diabetes and metabolic syndrome: do the rare variants associate with increased carotid intima-media thicknessReport as inadecuate




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Cardiovascular Diabetology

, 9:79

First Online: 29 November 2010Received: 13 September 2010Accepted: 29 November 2010

Abstract

BackgroundRecent studies revealed that glucokinase regulatory protein GCKR variants rs780094 and rs1260326 are associated with serum triglycerides and plasma glucose levels. Here we analyzed primarily the association of these two variants with the lipid profile and plasma glucose levels in Hungarian subjects with type 2 diabetes mellitus and metabolic syndrome; and also correlated the genotypes with the carotid intima-media thickness records.

MethodsA total of 321 type 2 diabetic patients, 455 metabolic syndrome patients, and 172 healthy controls were genotyped by PCR-RFLP.

ResultsBoth GCKR variants were found to associate with serum triglycerides and with fasting plasma glucose. However, significant association with the development of type 2 diabetes mellitus and metabolic syndrome could not be observed. Analyzing the records of the patients, a positive association of prevalence the GCKR homozygous functional variants and carotid intima-media thickness was found in the metabolic syndrome patients.

ConclusionsOur results support that rs780094 and rs1260326 functional variants of the GCKR gene are inversely associated with serum triglycerides and fasting plasma glucose levels, as it was already reported for diabetic and metabolic syndrome patients in some other populations. Besides this positive replication, as a novel feature, our preliminary findings also suggest a cardiovascular risk role of the GCKR minor allele carriage based on the carotid intima-media thickness association.

6. List of abbreviationsBMIBody mass index

CIMTCarotid intima-media thickness

CADCoronary artery diseases

GCKGlucokinase

GCKRGlucokinase regulatory protein

MSMetabolic syndrome

SNPSSingle nucleotide polymorphisms

T2DMType 2 diabetes mellitus

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Author: Márton Mohás - Péter Kisfali - Luca Járomi - Anita Maász - Eszter Fehér - Veronika Csöngei - Noémi Polgár - Enikő

Source: https://link.springer.com/article/10.1186/1475-2840-9-79







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