Estradiol Valerate Pretreatment in Short Protocol GnRH-Agonist Cycles versus Combined Pretreatment with Oral Contraceptive Pills in Long Protocol GnRH-Agonist Cycles: A Randomised Controlled TrialReport as inadecuate




Estradiol Valerate Pretreatment in Short Protocol GnRH-Agonist Cycles versus Combined Pretreatment with Oral Contraceptive Pills in Long Protocol GnRH-Agonist Cycles: A Randomised Controlled Trial - Download this document for free, or read online. Document in PDF available to download.

BioMed Research International - Volume 2015 2015, Article ID 628056, 6 pages -

Research Article

INVICTA Fertility and Reproductive Centre, 80-172 Gdansk, Poland

Department of Nursing, Medical University, 80-952 Gdansk, Poland

INVICTA Fertility and Reproductive Centre, 00-019 Warsaw, Poland

Centre for Reproductive Medicine KRIOBANK, 15-879 Białystok, Poland

Department of Gynecology and Oncological Gynecology, Medical University, 15-276 Białystok, Poland

Department of Obstetrics and Gynaecology, Medical Centre of Postgraduate Education, 01-813 Warsaw, Poland

Received 8 October 2014; Accepted 7 March 2015

Academic Editor: Ursula Zollner

Copyright © 2015 Krzysztof Lukaszuk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The strategy of in vitro fertilization IVF procedures relies on the increasing pregnancy rate and decreasing the risk of premature ovulation and ovarian hyperstimulation syndrome. They are also designed to avoid weekend oocyte retrievals. Combined oral contraceptive OC pills are among the medicines used to accomplish these objectives. Alternatively, estradiol can be used instead of OC to obtain similar results. The aim of our study was to compare the differences in pregnancy rates PRs, implantation rates, and miscarriage rates between a short agonist protocol with estradiol priming and a long protocol with combined OC. Of the 298 women who participated in this study, 134 achieved clinical pregnancies 45.0%. A higher PR 58.4%, , compared to 40.3%, was achieved in the long protocol after OC pretreatment group. The implantation rate was also higher for this group 37.8% versus 28.0%; . The miscarriage rate was 15.0% for the long protocol after OC pretreatment group and 20.4% for the short agonist group . The short agonist protocol required a 5.7% lower human menopausal gonadotropin hMG dosage than the long protocol but surprisingly the number of oocytes retrieved was also smaller.





Author: Krzysztof Lukaszuk, Joanna Liss, Michal Kunicki, Waldemar Kuczynski, Ewa Pastuszek, Grzegorz Jakiel, Lukasz Plociennik, Krz

Source: https://www.hindawi.com/



DOWNLOAD PDF




Related documents