Towards Defining Molecular Determinants Recognized by Adaptive Immunity in Allergic Disease: An Inventory of the Available DataReport as inadecuate

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Journal of AllergyVolume 2010 2010, Article ID 628026, 12 pages

Research Article

The Immune Epitope Database IEDB, La Jolla Institute for Allergy & Immunology LIAI, La Jolla, CA 92037, USA

School of Medicine, Allergy and Immunology, University of California, San Diego, La Jolla, CA 92093, USA

Food Allergy Research and Resource Program, University of Nebraska-Lincoln, Lincoln, NE 68583, USA

Received 6 December 2010; Accepted 20 December 2010

Academic Editor: Fabienne Rancé

Copyright © 2010 Kerrie Vaughan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Adaptive immune responses associated with allergic reactions recognize antigens from a broad spectrum of plants and animals. Herein a meta-analysis was performed on allergy-related data from the immune epitope database IEDB to provide a current inventory and highlight knowledge gaps and areas for future work. The analysis identified over 4,500 allergy-related epitopes derived from 270 different allergens. Overall, the distribution of the data followed expectations based on the nature of allergic responses. Namely, the majority of epitopes were defined for B cells-antibodies and IgE-mediated reactivity, and relatively fewer T-cell epitopes, mostly CD4

-class II. Interestingly, the majority of food allergen epitopes were B-cells epitopes whereas a fairly even number of B- and T-cell epitopes were defined for airborne allergens. In addition, epitopes from nonhumans hosts were mostly T-cell epitopes. Overall, coverage of known allergens is sparse with data available for only ~17% of all allergens listed by the IUIS database. Thus, further research would be required to provide a more balanced representation across different allergen categories. Furthermore, inclusion of nonpeptidic epitopes in the IEDB also allows for inventory and analysis of immunological data associated with drug and contact allergen epitopes. Finally, our analysis also underscores that only a handful of epitopes have thus far been investigated for their immunotherapeutic potential.

Author: Kerrie Vaughan, Jason Greenbaum, Yohan Kim, Randi Vita, Jo Chung, Bjoern Peters, David Broide, Richard Goodman, Howard Gre



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