Comparison of Quantiferon Test with Tuberculin Skin Test for the Detection of Tuberculosis Infection in ChildrenReport as inadecuate




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Inflammation

, Volume 35, Issue 4, pp 1518–1524

First Online: 26 April 2012

Abstract

The efficacy of Quantiferon-TB gold test QFT-GIT remains to be documented in pediatric population. Tuberculin skin test TST is a conventional test available for the diagnosis of latent tuberculosis infection LTBI. We aimed to investigate the concordance between QFT-GIT and TST in children with and without tuberculosis infection. Ninety-seven patients, aged 3 months–14 years, admitted to pediatric outpatient clinics of Dr. Sadi Konuk Training Hospital Bakırköy, Turkey between March 2008 and April 2009 were recruited. Demographic features, TST results, history of exposure to active tuberculosis TB, chest X-ray findings, clinical history, presence of Bacillus Calmette Guerin BCG vaccination scar were recorded. Patients were categorized into four groups namely, active TB, LTBI, no TB and healthy. It was found that BCG scar positivity did not influence QFT-GIT results. There was a statistically significant agreement between QFT-GIT and TST results κ = 0.486; p < 0.01. In patients ≥5 years of age, TST positivity and QFT positivity had a significant relationship p < 0.01. In all patient groups, sensitivity and specificity was 65.85 % and 82.14 %, respectively. In active TB group, TST and QFT-GIT results demonstrated significant agreement ratio of 40.8 % κ = 0.364; p < 0.01. Sensitivity and specificity was 100 % and 30 %, respectively. Utilization of QFT-GIT in the diagnosis of LTBI reduces false-positive results and prevents unnecessary treatment with INH and its adverse effects.

KEY WORDStuberculosis quantiferon tuberculin skin test BCG  Download fulltext PDF



Author: Hatice Onur - Sami Hatipoğlu - Vefik Arıca - Nevin Hatipoğlu - Seçil Gunher Arıca

Source: https://link.springer.com/



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