Left ventricular diastolic dyssynchrony assessed with phase analysis of gated myocardial perfusion SPECT: a comparison with tissue Doppler imagingReport as inadecuate




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European Journal of Nuclear Medicine and Molecular Imaging

, 38:2031

First Online: 18 August 2011Received: 26 February 2011Accepted: 15 June 2011

Abstract

PurposeThe aim of the current study was to evaluate the feasibility of phase analysis on gated myocardial perfusion SPECT GMPS for the assessment of left ventricular LV diastolic dyssynchrony in a head-to-head comparison with tissue Doppler imaging TDI.

MethodsThe population consisted of patients with end-stage heart failure of New York Heart Association functional class III or IV with a reduced LV ejection fraction of ≤35%. LV diastolic dyssynchrony was calculated using TDI as the maximal time delay between early peak diastolic velocities of two opposing left ventricle walls diastolic mechanical delay. Significant LV diastolic dyssynchrony was defined as a diastolic mechanical delay of >55 ms on TDI. Furthermore, phase analysis on GMPS was performed to evaluate LV diastolic dyssynchrony; diastolic phase standard deviation SD and histogram bandwidth HBW were used as markers of LV diastolic dyssynchrony.

ResultsA total of 150 patients 114 men, mean age 66.0 ± 10.4 years with end-stage heart failure were enrolled. Both diastolic phase SD r = 0.81, p < 0.01 and diastolic HBW r = 0.75, p < 0.01 showed good correlations with LV diastolic dyssynchrony on TDI. Additionally, patients with LV diastolic dyssynchrony on TDI >55 ms showed significantly larger diastolic phase SD 68.1 ± 13.4° vs. 40.7 ± 14.0°, p < 0.01 and diastolic HBW 230.6 ± 54.3° vs. 129.0 ± 55.6°, p < 0.01 as compared to patients without LV diastolic dyssynchrony on TDI ≤55 ms. Finally, phase analysis on GMPS showed a good intra- and interobserver reproducibility for the determination of diastolic phase SD ICC 0.97 and 0.88 and diastolic HBW ICC 0.98 and 0.93.

ConclusionPhase analysis on GMPS showed good correlations with TDI for the assessment of LV diastolic dyssynchrony.

KeywordsEchocardiography Heart failure Imaging Mechanics Myocardial perfusion imaging  Download fulltext PDF



Author: Mark J. Boogers - Ji Chen - Caroline E. Veltman - Rutger J. van Bommel - Eline A. Q. Mooyaart - Imad Al Younis - Bern

Source: https://link.springer.com/







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