Plasma osteoprotegerin is related to carotid and peripheral arterial disease, but not to myocardial ischemia in type 2 diabetes mellitusReport as inadecuate




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Cardiovascular Diabetology

, 10:76

First Online: 12 August 2011Received: 03 August 2011Accepted: 12 August 2011

Abstract

BackgroundCardiovascular disease CVD is frequent in type 2 diabetes mellitus patients due to accelerated atherosclerosis. Plasma osteoprotegerin OPG has evolved as a biomarker for CVD. We examined the relationship between plasma OPG levels and different CVD manifestations in type 2 diabetes.

MethodsType 2 diabetes patients without known CVD referred consecutively to a diabetes clinic for the first time n = 305, aged: 58.6 ± 11.3 years, diabetes duration: 4.5 ± 5.3 years were screened for carotid arterial disease, peripheral arterial disease, and myocardial ischemia by means of carotid artery ultrasonography, peripheral ankle and toe systolic blood pressure measurements, and myocardial perfusion scintigraphy MPS. In addition, plasma OPG concentrations and other CVD-related markers were measured.

ResultsThe prevalence of carotid arterial disease, peripheral arterial disease, and myocardial ischemia was 42%, 15%, and 30%, respectively. Plasma OPG was significantly increased in patients with carotid and peripheral arterial disease compared to patients without p < 0.001, respectively, however, this was not the case for patients with myocardial ischemia versus those without p = 0.71. When adjusted for age, HbA1c and U-albumin creatinine ratio in a multivariate logistic regression analysis, plasma OPG remained strongly associated with carotid arterial disease adjusted OR: 2.12; 95% CI: 1.22-3.67; p = 0.008, but not with peripheral arterial disease or myocardial ischemia.

ConclusionsIncreased plasma OPG concentration is associated with carotid and peripheral arterial disease in patients with type 2 diabetes, whereas no relation is observed with respect to myocardial ischemia on MPS. The reason for this discrepancy is unknown.

Trial registration numberat http:-www.clinicaltrial.gov: NCT00298844

List of abbreviationsABIankle-brachial index

CIMTcarotid intima-media thickness

CVDcardiovascular disease

MPSmyocardial perfusion scintigraphy

OPGosteoprotegerin

PADperipheral arterial disease

RANK-Lreceptor activator of nuclear factor-B ligand

TRAILTNF-related apoptosis inducing ligand

TSPItoe systolic blood pressure.

Electronic supplementary materialThe online version of this article doi:10.1186-1475-2840-10-76 contains supplementary material, which is available to authorized users.

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Author: Mikael K Poulsen - Mads Nybo - Jordi Dahl - Susanne Hosbond - Tina S Poulsen - Allan Johansen - Poul F Høilund-Carlsen

Source: https://link.springer.com/article/10.1186/1475-2840-10-76







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