Effects of a single injection of teriparatide on bone turnover markers in postmenopausal womenReport as inadecuate




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Osteoporosis International

, Volume 24, Issue 1, pp 219–226

First Online: 24 October 2012Received: 24 July 2012Accepted: 11 September 2012

Abstract

SummaryThis study investigated the effects of a single administration of teriparatide on bone turnover markers in postmenopausal women. Teriparatide caused a transient increase in bone resorption and inhibition of bone formation followed by a subsequent increase in bone formation and a decrease in resorption that lasted at least 1 week.

IntroductionThis study aims to investigate the effects of a single subcutaneous administration of teriparatide on bone turnover markers to elucidate why once weekly intermittent administration of teriparatide is effective on osteoporosis.

MethodsPharmacokinetics and calcium metabolism and bone turnover parameters were measured in 30 postmenopausal women after two doses of teriparatide 28.2 or 56.5 μg injection or placebo in a randomized, double-blind, placebo-controlled study.

ResultsTeriparatide plasma concentration increased in a dose-dependent manner, and the maximum concentration was achieved 1 h after injection. Serum levels of calcium and phosphorus were transiently increased and decreased after teriparatide injection, respectively. Calcium metabolism returned to baseline levels 24 h later. Two days after injection, the serum level of 1,25-dihydroxy vitamin D was increased by ~80 % from baseline for both doses of teriparatide. Serum levels of osteocalcin and procollagen type I N-terminal propeptide decreased during the first 24 h followed by a ~10 % increase for 14 days. The serum level of cross-linked N-telopeptide NTX of type I collagen increased during the first 24 h followed by a 10 to 12 % dose-dependent suppression from baseline for 14 days. Urinary cross-linked C-telopeptide of type I collagen changes occurred in the same direction as serum NTX, but not dose dependently.

ConclusionA single administration of teriparatide caused an immediate, transient increase in bone resorption and inhibited bone formation followed by an increase in bone formation and decrease in resorption for ≥1 week. These findings may provide proof for the effect of a once-weekly regimen of teriparatide on bone turnover.

KeywordsBone formation Bone resorption Bone turnover marker Human Single administration Teriparatide  Download fulltext PDF



Author: M. Shiraki - T. Sugimoto - T. Nakamura

Source: https://link.springer.com/







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