Effect of cinnamon on gastric emptying, arterial stiffness, postprandial lipemia, glycemia, and appetite responses to high-fat breakfastReport as inadecuate




Effect of cinnamon on gastric emptying, arterial stiffness, postprandial lipemia, glycemia, and appetite responses to high-fat breakfast - Download this document for free, or read online. Document in PDF available to download.

Cardiovascular Diabetology

, 10:78

First Online: 07 September 2011Received: 23 August 2011Accepted: 07 September 2011

Abstract

BackgroundCinnamon has been shown to delay gastric emptying of a high-carbohydrate meal and reduce postprandial glycemia in healthy adults. However, it is dietary fat which is implicated in the etiology and is associated with obesity, type 2 diabetes and cardiovascular disease. We aimed to determine the effect of 3 g cinnamon Cinnamomum zeylanicum on GE, postprandial lipemic and glycemic responses, oxidative stress, arterial stiffness, as well as appetite sensations and subsequent food intake following a high-fat meal.

MethodsA single-blind randomized crossover study assessed nine healthy, young subjects. GE rate of a high-fat meal supplemented with 3 g cinnamon or placebo was determined using the C octanoic acid breath test. Breath, blood samples and subjective appetite ratings were collected in the fasted and during the 360 min postprandial period, followed by an ad libitum buffet meal. Gastric emptying and 1-day fatty acid intake relationships were also examined.

ResultsCinnamon did not change gastric emptying parameters, postprandial triacylglycerol or glucose concentrations, oxidative stress, arterial function or appetite p < 0.05. Strong relationships were evident p < 0.05 between GE Thalf and 1-day palmitoleic acid r = -0.78, eiconsenoic acid r = -0.84 and total omega-3 intake r = -0.72. The ingestion of 3 g cinnamon had no effect on GE, arterial stiffness and oxidative stress following a HF meal.

Conclusions3 g cinnamon did not alter the postprandial response to a high-fat test meal. We find no evidence to support the use of 3 g cinnamon supplementation for the prevention or treatment of metabolic disease. Dietary fatty acid intake requires consideration in future gastrointestinal studies.

Trial registrationTrial registration number: at http:-www.clinicaltrial.gov: NCT01350284

Keywordsgastrointestinal antioxidant capacity obesity type 2 diabetes polyphenols fatty acids omega-3 fatty acids List of abbreviationsGEgastric emptying

T2Dtype 2 diabetes

CVDcardiovascular disease

HFhigh-fat

OGTToral glucose tolerance test

NOnitric oxide

ROSreactive oxygen species

GIgastrointestinal

GLP-1glucagon-like peptide-1

CCKcholecystokinin

BPblood pressure

VASvisual analogue scale

Thalfgastric half emptying time

Tlaglag phase

Tlatlatency time

Tascascension time

DVPdigital volume pulse

SIstiffness index

RIreflection index

LOOHlipid hydroperoxides

SNSsympathetic nervous system

Electronic supplementary materialThe online version of this article doi:10.1186-1475-2840-10-78 contains supplementary material, which is available to authorized users.

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Author: Oonagh Markey - Conor M McClean - Paul Medlow - Gareth W Davison - Tom R Trinick - Ellie Duly - Amir Shafat

Source: https://link.springer.com/article/10.1186/1475-2840-10-78







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