Effects of calcium channel blockers on glucose tolerance, inflammatory state, and circulating progenitor cells in non-diabetic patients with essential hypertension: a comparative study between Azelnidipine and amlodipine on GlucosReport as inadecuate




Effects of calcium channel blockers on glucose tolerance, inflammatory state, and circulating progenitor cells in non-diabetic patients with essential hypertension: a comparative study between Azelnidipine and amlodipine on Glucos - Download this document for free, or read online. Document in PDF available to download.

Cardiovascular Diabetology

, 10:79

First Online: 10 September 2011Received: 26 June 2011Accepted: 10 September 2011

Abstract

BackgroundHypertension is associated with impaired glucose tolerance and insulin resistance. Medical treatment that interferes with various steps in the renin-angiotensin system improves glucose tolerance and insulin resistance. However, it remains unclear if long-acting calcium channel blockers CCBs such as azelnidipine and amlodipine affect glucose tolerance and insulin resistance in clinical practice.

MethodsSeventeen non-diabetic patients with essential hypertension who had controlled blood pressure levels using amlodipine 5 mg-day were enrolled in this study. After randomization, either azelnidipine 16 mg-day or amlodipine 5 mg-day was administered in a crossover design for 12-weeks. At baseline and the end of each CCB therapy, samples of blood and urine were collected and 75 g oral glucose tolerance test OGTT was performed. In addition, hematopoietic progenitor cells HPCs were measured at each point by flow cytometry and endothelial functions were measured by fingertip pulse amplitude tonometry using EndoPAT.

ResultsAlthough blood pressure levels were identical after each CCB treatment, the heart rate significantly decreased after azelnidipine administration than that after amlodipine administration P < 0.005. Compared with amlodipine administration, azelnidipine significantly decreased levels of glucose and insulin 120 min after the 75 g OGTT both P < 0.05. Serum levels of high-sensitivity C-reactive protein P = 0.067 and interleukin-6 P = 0.035 were decreased. Although endothelial functions were not different between the two medication groups, the number of circulating HPCs was significantly increased after azelnidipine administration P = 0.016.

ConclusionsThese results suggest that azelnidipine treatment may have beneficial effects on glucose tolerance, insulin sensitivity, the inflammatory state, and number of circulating progenitor cells in non-diabetic patients with essential hypertension.

Electronic supplementary materialThe online version of this article doi:10.1186-1475-2840-10-79 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Author: Kosuke Fukao - Kazunori Shimada - Makoto Hiki - Takashi Kiyanagi - Kuniaki Hirose - Atsumi Kume - Hiromichi Ohsaka - Rie M

Source: https://link.springer.com/article/10.1186/1475-2840-10-79



DOWNLOAD PDF




Related documents