Effects of patient movement on measurements of myocardial blood flow and viability in resting 15O-water PET studiesReport as inadecuate




Effects of patient movement on measurements of myocardial blood flow and viability in resting 15O-water PET studies - Download this document for free, or read online. Document in PDF available to download.

Journal of Nuclear Cardiology

, Volume 19, Issue 3, pp 524–533

First Online: 08 February 2012Received: 05 April 2011Accepted: 12 January 2012

Abstract

BackgroundPatient movement has been considered an important source of errors in cardiac PET. This study was aimed at evaluating the effects of such movement on myocardial blood flow MBF and perfusable tissue fraction PTF measurements in intravenous O-water PET.

MethodsNineteen O-water scans were performed on ten healthy volunteers and three patients with severe cardiac dysfunction under resting conditions. Motions of subjects during scans were estimated by monitoring locations of markers on their chests using an optical motion-tracking device. Each sinogram of the dynamic emission frames was corrected for subject motion. Variation of regional MBF and PTF with and without the motion corrections was evaluated.

ResultsIn nine scans, motions during O-water scan inter-frame IF motion and misalignments relative to the transmission scan inter-scan IS motion larger than the spatial resolution of the PET scanner 4.0 mm were both detected by the optical motion-tracking device. After correction for IF motions, MBF values changed from 0.845 ± 0.366 to 0.780 ± 0.360 mL-minute-g P < .05. In four scans with only IS motion detected, PTF values changed significantly from 0.465 ± 0.118 to 0.504 ± 0.087 g-mL P< .05, but no significant change was found in MBF values.

ConclusionsThis study demonstrates that IF motion during O-water scan at rest can be source of error in MBF measurement. Furthermore, estimated MBF is less sensitive than PTF values to misalignment between transmission and O-water emission scans.

KeywordsMyocardial blood flow water-perfusable tissue fraction PET myocardial perfusion imaging motion correction O-labeled water This study was supported by a Research Grant from the New Energy and Industrial Technology Development Organization NEDO, Japan; a Grant for Translational Research from the Ministry of Health, Labour and Welfare MHLW of Japan; a Grant for Advanced Medical Technology from the Ministry of Health, Labour and Welfare MHLW of Japan; the Program for Promotion of Fundamental Studies in Health Science of the Organization for Pharmaceutical Safety and Research of Japan; and a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology MEXT of Japan.

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Author: Kazuhiro Koshino - Hiroshi Watabe - Junichiro Enmi - Yoshiyuki Hirano - Tsutomu Zeniya - Shinji Hasegawa - Takuya Hayashi -

Source: https://link.springer.com/







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