Comparison of zotarolimus-eluting and sirolimus-eluting coronary stents: a study from the Western Denmark Heart RegistryReport as inadecuate




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BMC Cardiovascular Disorders

, 12:84

Coronary artery disease

Abstract

BackgroundWe evaluated the effectiveness and safety of a zotarolimus-eluting ZES versus a sirolimus-eluting SES coronary stent in a large cohort of patients treated with one of these stents in Western Denmark.

MethodsA total of 6,122 patients treated with ZES n=2,282 or SES n=3,840 were followed for up to 27 months. We ascertained clinical outcomes based on national medical databases.

ResultsIncidence of target lesion revascularization no. per 100 person-years was 5.3 in the ZES group compared to 1.9 in the SES group adjusted hazard ratio HR=2.19, 95% confidence intervals CI: 1.39-3.47; p=0.001. All-cause mortality was also higher in the ZES group ZES: 6.3; SES: 3.3; adjusted HR=1.34, 95% CI: 1.05-1.72; p=0.02, while stent thrombosis ZES: 1.2; SES: 0.5; adjusted HR=1.98, 95% CI: 0.75-5.23; p=0.14 did not differ significantly.

ConclusionsIn agreement with previously published randomised data, this observational study indicated that the ZES was associated with an increased risk of death and TLR in a large cohort of consecutive patients.

KeywordsZotarolimus Sirolimus Stent Mortality Stent thrombosis Diabetes mellitus AbbreviationCIConfidence interval

DESDrug-eluting stent

HRHazard ratio

MIMyocardial infarction

PCIPercutaneous coronary intervention

SESSirolimus-eluting stent

SORT OUTDaniS h O rganisation for R andomised T rials with Clinical OUT come

STEMIST-segment elevation MI

TLRTarget lesion revascularization

TVRTarget vessel revascularization

WDHRWestern Denmark Heart Registry

ZESZotarolimus-eluting stent.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2261-12-84 contains supplementary material, which is available to authorized users.

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Author: Michael Maeng - Lisette Okkels Jensen - Anne Kaltoft - Hans-Henrik Tilsted - Evald Høj Christiansen - Per Thayssen - Mort

Source: https://link.springer.com/article/10.1186/1471-2261-12-84



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