Initial investigation of 18F-NaF PET-CT for identification of vertebral sites amenable to surgical revision after spinal fusion surgeryReport as inadecuate




Initial investigation of 18F-NaF PET-CT for identification of vertebral sites amenable to surgical revision after spinal fusion surgery - Download this document for free, or read online. Document in PDF available to download.

European Journal of Nuclear Medicine and Molecular Imaging

, Volume 39, Issue 11, pp 1737–1744

First Online: 16 August 2012Received: 15 February 2012Accepted: 13 July 2012

Abstract

PurposeA pilot study was performed in patients with recurrent back pain after spinal fusion surgery to evaluate the ability of F-NaF PET-CT imaging to correctly identify those requiring surgical intervention and to locate a site amenable to surgical intervention.

MethodsIn this prospective study 22 patients with recurrent back pain after spinal surgery and with equivocal findings on physical examination and CT were enrolled for evaluation with F-NaF PET-CT. All PET-CT images were prospectively reviewed with the primary objective of identifying or ruling out the presence of lesions amenable to surgical intervention. The PET-CT results were then validated during surgical exploration or clinical follow-up of at least 15 months.

ResultsAbnormal F-NaF foci were found in 16 of the 22 patients, and surgical intervention was recommended. These foci were located at various sites: screws, cages, rods, fixation hardware, and bone grafts. In 6 of the 22 patients no foci requiring surgical intervention were found. Validation of the results by surgery 15 patients or on clinical follow-up 7 patients showed that F-NaF PET-CT correctly predicted the presence of an abnormality requiring surgical intervention in 15 of 16 patients and was falsely positive in 1 of 16.

ConclusionIn this initial investigation, F-NaF PET-CT imaging showed potential utility for evaluation of recurrent symptoms after spinal fusion surgery by identifying those patients requiring surgical management.

KeywordsFluoride PET-CT Spine Spinal fusion  Download fulltext PDF



Author: Andrew Quon - Robert Dodd - Andrei Iagaru - Marcelo Rodrigues de Abreu - Sergio Hennemann - Jose Maria Alves Neto - Clar

Source: https://link.springer.com/







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