Changes in Plasma Kynurenic Acid Concentration in Septic Shock Patients Undergoing Continuous Veno-Venous HaemofiltrationReport as inadecuate




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Inflammation

, Volume 37, Issue 1, pp 223–234

First Online: 17 September 2013

Abstract

Kynurenic acid KYNA is one of the end products of tryptophan metabolism. The aim of this study was to analyse plasma KYNA concentration in septic shock patients SSP with acute kidney injury AKI undergoing continuous veno-venous haemofiltration CVVH. Changes in KYNA content were compared to alterations in the levels of procalcitonin PCT, C-reactive protein and lactate. Adult SSP with AKI were examined. Measurements were conducted at seven time points: before beginning CVVH and at 6, 12, 24, 48, 72 and 96 h after the beginning of CVVH. Based on clinical outcomes, the data were analysed separately for survivors and non-survivors. Twenty-seven patients were studied. CVVH was associated with reduced plasma KYNA concentration only in survivors. Plasma KYNA concentration correlated with the levels of lactate and PCT only in survivors. 1 CVVH reduced plasma KYNA concentration only in survivors; 2 lack of this reduction may predict fatal outcomes in SSP.

KEY WORDSkynurenic acid inflammatory markers continuous veno-venous haemofiltration septic shock acute kidney injury  Download fulltext PDF



Author: Wojciech Dabrowski - Tomasz Kocki - Jacek Pilat - Jolanta Parada-Turska - Manu L. N. G. Malbrain

Source: https://link.springer.com/







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