Impact of the LDL subfraction phenotype on Lp-PLA2 distribution, LDL modification and HDL composition in type 2 diabetesReport as inadecuate




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Cardiovascular Diabetology

, 12:112

First Online: 05 August 2013Received: 06 June 2013Accepted: 03 August 2013

Abstract

BackgroundQualitative alterations of lipoproteins underlie the high incidence of atherosclerosis in diabetes. The objective of this study was to assess the impact of low-density lipoprotein LDL subfraction phenotype on the qualitative characteristics of LDL and high-density lipoprotein HDL in patients with type 2 diabetes.

MethodsOne hundred twenty two patients with type 2 diabetes in poor glycemic control and 54 healthy subjects were included in the study. Patients were classified according to their LDL subfraction phenotype. Seventy-seven patients presented phenotype A whereas 45 had phenotype B. All control subjects showed phenotype A. Several forms of modified LDL, HDL composition and the activity and distribution of lipoprotein-associated phospholipase A2 Lp-PLA2 were analyzed.

ResultsOxidized LDL, glycated LDL and electronegative LDL were increased in both groups of patients compared with the control group. Patients with phenotype B had increased oxidized LDL and glycated LDL concentration than patients with phenotype A. HDL composition was abnormal in patients with diabetes, being these abnormalities more marked in patients with phenotype B. Total Lp-PLA2 activity was higher in phenotype B than in phenotype A or in control subjects. The distribution of Lp-PLA2 between HDL and apoB-containing lipoproteins differed in patients with phenotype A and phenotype B, with higher activity associated to apoB-containing lipoproteins in the latter.

ConclusionsThe presence of LDL subfraction phenotype B is associated with increased oxidized LDL, glycated LDL and Lp-PLA2 activity associated to apoB-containing lipoproteins, as well as with abnormal HDL composition.

KeywordsLow-density lipoprotein High-density lipoprotein Lipoprotein-associated phospholipase A2 Modified LDL Type 2 diabetes LDL subfraction phenotype Electronic supplementary materialThe online version of this article doi:10.1186-1475-2840-12-112 contains supplementary material, which is available to authorized users.

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Author: Jose Luis Sánchez-Quesada - Irene Vinagre - Elena De Juan-Franco - Juan Sánchez-Hernández - Rosa Bonet-Marques - Francisc

Source: https://link.springer.com/article/10.1186/1475-2840-12-112







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