Vitamin D supplementation in patients with diabetes mellitus type 2 on different therapeutic regimens: a one-year prospective studyReport as inadecuate




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Cardiovascular Diabetology

, 12:113

First Online: 07 August 2013Received: 26 May 2013Accepted: 05 August 2013

Abstract

BackgroundLittle or no research has determined the effect of vitamin D3 supplementation in conjunction with pharmacological and non-pharmacological approaches in the diabetes mellitus type 2 DMT2 patients. The objective of this study was to determine the effect of vitamin D3 supplementation in a cohort of Saudi DMT2 population on diet, insulin and-or different oral hypoglycemic agents and compare them with a non-DMT2 control cohort.

MethodsA total of 499 randomly selected Saudi subjects divided into 8 groups Non-DMT2 Control = 151; Rosiglitazone alone = 49; Diet = 15; Insulin alone = 55; Insulin + Orals = 12; Metformin alone = 121; Oral agents combination = 37; Sulphonylurea alone = 59 were included in this 12-month interventional study. All DMT2 patients were given 2000 IU vitamin D3 daily, while the control group received none but were advised to increase sun exposure. Anthropometrics, glucose, lipid profile and 25-hydroxyvitamin D 25-OHVitD were measured at baseline, 6 and 12 months.

ResultsCirculating 25-OHVitD concentrations improved in all patient groups. The metformin group showed the highest change in circulating vitamin D levels both at 6 months 62.6% and 12 months 50.6% as compared to baseline p < 0.001. No significant changes were observed in the BMI and glucose in any of the DMT2 groups. In contrast, the insulin + oral agents group showed more significant improvements in the metabolic profile, which included triglycerides and total cholesterol, as well as systolic blood pressure and HDL-cholesterol in males. Also, significant decreases in triglycerides were observed in the rosiglitazone and insulin + oral hypoglycemic agent groups both at 6 and 12 months of supplementation both p-values <0.001.

ConclusionWhile in all DMT2 groups circulating levels of 25-OHVitD increased after supplementation, in DMT2 patients on insulin in combination with other drugs benefitted the most in improving cardiovascular risk. Metformin improves 25-hydroxyvitamin D levels but did not seem to confer other added cardiometabolic benefits.

KeywordsVitamin D Vitamin D supplementation Diabetes mellitus Anti-diabetes therapies Electronic supplementary materialThe online version of this article doi:10.1186-1475-2840-12-113 contains supplementary material, which is available to authorized users.

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Author: Khalid M Alkharfy - Nasser M Al-Daghri - Shaun B Sabico - Abdulaziz Al-Othman - Osama Moharram - Majed S Alokail - Youse

Source: https://link.springer.com/article/10.1186/1475-2840-12-113







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