Osteoporosis Assessment Questionnaire-Physical Function OPAQ-PF: a psychometrically validated osteoporosis-targeted patient reported outcome measure of daily activities of physical functionReport as inadecuate




Osteoporosis Assessment Questionnaire-Physical Function OPAQ-PF: a psychometrically validated osteoporosis-targeted patient reported outcome measure of daily activities of physical function - Download this document for free, or read online. Document in PDF available to download.

Osteoporosis International

, Volume 25, Issue 6, pp 1775–1784

First Online: 16 April 2014Received: 14 October 2013Accepted: 14 March 2014

Abstract

SummaryThe purpose of this study was to evaluate the measurement properties of the Osteoporosis Assessment Questionnaire-Physical Functioning OPAQ-PF. Based on this study, the OPAQ-PF has confirmed unidimensionality and acceptable reliability, construct validity, and sensitivity to change in a recent fracture-no recent fracture osteoporosis sample.

MethodsDimensionality was established through exploratory and confirmatory factor analysis. Patients completed three patient reported outcome PRO measures and four performance-based measures PBMs at baseline to enable an evaluation of construct validity. Patients without a recent fracture completed the OPAQ-PF 2 weeks after baseline to enable an evaluation of test–retest reliability. Ability to detect change and interpretation of change were investigated following completion of the OPAQ-PF 12 and 24 weeks postbaseline by patients with a recent fracture.

ResultsA prospective psychometric validation study in 144 postmenopausal women, with moderate to severe osteoporosis, 37 of whom had experienced a recent fragility fracture <6 weeks. Unidimensionality was established for the OPAQ-PF by factor analysis. The OPAQ-PF had good internal consistency α = 0.974 and test–retest reliability mean intraclass correlation coefficient ICC 0.993. The OPAQ-PF differentiated between patients with-without recent fracture, and by severity of osteoarthritis; it correlated strongly with hypothesized-related scales and PBMs r > 0.3, p < 0.001. Ability to detect change was established with high correlations between changes in OPAQ-PF score and changes in global concept scores in recent fracture patients r ≥ 0.6, 24-week change. Effect size of change on OPAQ-PF score increased by level of global change p < 0.001. Anchor-based methods identified an OPAQ-PF change of 10 at an individual patient level and 20 at a group level as meaningful to patients.

ConclusionsThe OPAQ-PF has confirmed unidimensionality and acceptable reliability, construct validity, and sensitivity to change in a recent fracture-no recent fracture osteoporosis sample.

KeywordsOPAQ-PF Osteoporosis Outcomes assessment Patient reported outcomes Physical function Psychometrics  Download fulltext PDF



Author: A. Nixon - C. Kerr - H. Doll - A. N. Naegeli - S. L. Shingler - K. Breheny - R. Burge - D. T. Gold - S. Silverman

Source: https://link.springer.com/







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