Circulating concentrations of GLP-1 are associated with coronary atherosclerosis in humansReport as inadecuate




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Cardiovascular Diabetology

, 12:117

First Online: 16 August 2013Received: 29 July 2013Accepted: 30 July 2013

Abstract

BackgroundGLP-1 is an incretine hormone which gets secreted from intestinal L-cells in response to nutritional stimuli leading to pancreatic insulin secretion and suppression of glucagon release. GLP-1 further inhibits gastric motility and reduces appetite which in conjunction improves postprandial glucose metabolism. Additional vasoprotective effects have been described for GLP-1 in experimental models. Despite these vasoprotective actions, associations between endogenous levels of GLP-1 and cardiovascular disease have yet not been investigated in humans which was the aim of the present study.

MethodsGLP-1 serum levels were assessed in a cohort of 303 patients receiving coronary CT-angiography due to typical or atypical chest pain.

ResultsGLP-1 was found to be positively associated with total coronary plaque burden in a fully adjusted model containing age, sex, BMI, hypertension, diabetes mellitus, smoking, triglycerides, LDL-C low density lipoprotein cholesterol, hsCRP high-sensitive C-reactive protein, and eGFR estimated glomerular filtration rate OR: 2.53 95% CI: 1.12 – 6.08; p = 0.03.

ConclusionCirculating GLP-1 was found to be positivity associated with coronary atherosclerosis in humans. The clinical relevance of this observation needs further investigations.

KeywordsGLP-1 Atherosclerosis Coronary CT angiography AbbreviationsACE-IAngiotensin-converting enzyme inhibitors

AHAAmerican Heart Association

ARBAngiotensin II receptor blocker

BMIBody mass index

CADCoronary artery disease

DPP-4Dipeptidyl peptidase-4

eGFREstimate glomerular filtration rate

GLP-1Glucagon-like peptide 1

HDL-CHigh density lipoprotein cholesterol

hsCRPHigh-sensitive C-reactive protein

IL6Interleukin 6

LDL-CLow density lipoprotein cholesterol

PATPericardial adipose tissue

TNFαTumor necrosis factor alpha.

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Author: Katja Piotrowski - Melanie Becker - Julia Zugwurst - Ingeborg Biller-Friedmann - Gerald Spoettl - Martin Greif - Alexander 

Source: https://link.springer.com/article/10.1186/1475-2840-12-117



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