MicroRNA Dysregulation in Cystic FibrosisReport as inadecuate




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Mediators of Inflammation - Volume 2015 2015, Article ID 529642, 7 pages -

Review ArticleDepartment of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland

Received 17 December 2014; Accepted 6 January 2015

Academic Editor: Nades Palaniyar

Copyright © 2015 Paul J. McKiernan and Catherine M. Greene. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The cystic fibrosis lung is a complex milieu comprising multiple factors that coordinate its physiology. MicroRNAs are regulatory factors involved in most biological processes and it is becoming increasingly clear that they play a key role in the development and manifestations of CF lung disease. These small noncoding RNAs act posttranscriptionally to inhibit protein production. Their involvement in the pathogenesis of CF lung disease stems from the fact that their expression is altered in vivo in the CF lung due to intrinsic and extrinsic factors; to date defective chloride ion conductance, endoplasmic reticulum stress, inflammation, and infection have been implicated in altering endogenous miRNA expression in this setting. Here, the current state-of-the-art and biological consequences of altered microRNA expression in cystic fibrosis are reviewed.





Author: Paul J. McKiernan and Catherine M. Greene

Source: https://www.hindawi.com/



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