T1 Mapping for Characterization of Intracellular and Extracellular Myocardial Diseases in Heart FailureReport as inadecuate




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Current Cardiovascular Imaging Reports

, 7:9287

Topical Collection on Heart Failure and Targeted Imaging

Abstract

Heart failure HF is a major and growing cause of morbidity and mortality. Despite initial successes, there have been few recent therapeutic advances. A better understanding of HF pathophysiology is needed with renewed focus on the myocardium itself. A new imaging technique is now available that holds promise. T1 mapping is a cardiovascular magnetic resonance CMR technique for non-invasive myocardial tissue characterization. T1 alters with disease. Pre-contrast native T1 changes with a number of processes such as fibrosis, edema and infiltrations. If a post contrast scan is also done, the extracellular volume fraction ECV can be measured, a direct measure of the interstitium and its reciprocal, the cell volume. This dichotomy is fundamental — and now measurable promising more targeted therapy and new insights into disease biology.

KeywordsT1 mapping Extracellular space Heart failure Extracellular volume fraction Diffuse fibrosis Intracellular space Cardiac remodelling Myocardial intracellular volume Myocytes Interstitium This article is part of the Topical Collection on Heart Failure and Targeted Imaging

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Author: Viviana Maestrini - Thomas A. Treibel - Steven K. White - Marianna Fontana - James C. Moon

Source: https://link.springer.com/







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