A general review of major global coagulation assays: thrombelastography, thrombin generation test and clot waveform analysisReport as inadecuate




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Thrombosis Journal

, 13:1

Global Assays in thrombosis, what are they and why do we need them?

Abstract

Thrombosis and hemorrhage are major contributors to morbidity and mortality. The traditional laboratory tests do not supply enough information to diagnose and treat patients timely and according to their phenotype. Global hemostasis tests might improve this circumstance. The viscoelastic tests ROTEM-TEG demonstrated to ameliorate treatment of acute hemorrhage in terms of decreased amount of transfusion and lowered costs. Thrombin generation measurement is indicative for thrombosis and might also become an important tool in managing hemorrhage. While the clot waveform analysis is less well known it could be of worth in staging sepsis patients, early detection of DIC and also in diagnosis and treatment monitoring of hemophiliac patients. Although in different degree all three methods still need more background, standardization and acceptance before a wide clinical application.

KeywordsGlobal coagulation assays Thrombosis Hemorrhage Hemophilia AbbreviationsaPTTActivated partial thromboplastin time

CATCalibrated automated thrombin generation

CWAClot waveform analysis

DICDisseminated intravascular coagulation

ETPEndogenous thrombin potential

INRInternational normalized ratio

LMWHLow weight molecular heparin

PPPPlatelet poor plasma

PRPPlatelet rich plasma

PTProthrombin time

TFTissue factor

TGThrombin generation

TGTThrombin generation test

TMThrombomodulin

VKAVitamin K antagonist.

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Author: Marcus D Lancé

Source: https://link.springer.com/article/10.1186/1477-9560-13-1



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