Positive association of tomato consumption with serum urate: support for tomato consumption as an anecdotal trigger of gout flaresReport as inadecuate




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BMC Musculoskeletal Disorders

, 16:196

First Online: 19 August 2015Received: 20 December 2014Accepted: 04 August 2015

Abstract

BackgroundGout is a consequence of an innate immune reaction to monosodium urate crystals deposited in joints. Acute gout attacks can be triggered by dietary factors that are themselves associated with serum urate levels. Tomato consumption is an anecdotal trigger of gout flares. This study aimed to measure the frequency of tomato consumption as a self-reported trigger of gout attacks in a large New Zealand sample set, and to test the hypothesis that tomato consumption is associated with serum urate levels.

MethodsTwo thousand fifty one New Zealanders of Māori, Pacific Island, European or other ancestry with clinically-ascertained gout were asked about gout trigger foods. European individuals from the Atherosclerosis Risk In Communities ARIC; n = 7517 Study, Cardiovascular Health Study CHS; n = 2151 and Framingham Heart Study FHS; n = 3052 were used to test, in multivariate-adjusted analyses, for association between serum urate and tomato intake.

ResultsSeventy one percent of people with gout reported having ≥1 gout trigger food. Of these 20 % specifically mentioned tomatoes, the 4 most commonly reported trigger food. There was association between tomato intake and serum urate levels in the ARIC, CHS and FHS combined cohort β = 0.66 μmolL increase in serum urate per additional serve per week; P = 0.006 - evident in both sexes men: β = 0.84 μmolL, P = 0.035; women: β = 0.59 μmolL , P = 0.041.

ConclusionsWhile our descriptive and observational data are unable to support the claim that tomato consumption is a trigger of gout attacks, the positive association between tomato consumption and serum urate levels suggests that the self-reporting of tomatoes as a dietary trigger by people with gout has a biological basis.

AbbreviationsARICAtherosclerosis Risk in Communities

CHSCardiovascular Health Study

FHSFramingham Heart Study

MSUMonosodium urate

NHANESNational Health and Nutrition Examination Survey

OATOrganic anion transporter

PCAPrincipal component analysis

SLCSolute carrier

Electronic supplementary materialThe online version of this article doi:10.1186-s12891-015-0661-8 contains supplementary material, which is available to authorized users.

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Author: Tanya J Flynn - Murray Cadzow - Nicola Dalbeth - Peter B Jones - Lisa K Stamp - Jennie Harré Hindmarsh - Alwyn S Todd

Source: https://link.springer.com/







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