Cerebral perfusion and glucose metabolism in Alzheimer’s disease and frontotemporal dementia: two sides of the same coinReport as inadecuate




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European Radiology

, Volume 25, Issue 10, pp 3050–3059

First Online: 22 April 2015Received: 15 December 2014Revised: 19 February 2015Accepted: 24 February 2015

Abstract

ObjectivesAlzheimer’s disease AD and frontotemporal FTD dementia can be differentiated using F-2-deoxy-2-fluoro-D-glucose FDG-PET. Since cerebral blood flow CBF is related to glucose metabolism, our aim was to investigate the extent of overlap of abnormalities between AD and FTD.

MethodsNormalized FDG-PET and arterial spin labelling ASL-MRI-derived CBF was measured in 18 AD patients age, 64 ± 8, 12 FTD patients age, 61 ± 8, and 10 controls age, 56 ± 10. Voxel-wise comparisons, region-of-interest ROI, correlation, and ROC curve analyses were performed.

ResultsVoxel-wise comparisons showed decreased CBF and FDG uptake in AD compared with controls and FTD in both precuneus and inferior parietal lobule IPL. Compared with controls and AD, FTD patients showed both hypometabolism and hypoperfusion in medial prefrontal cortex mPFC. ASL and FDG were related in precuneus r = 0.62, p < 0.001, IPL r = 0.61, p < 0.001, and mPFC across groups r = 0.74, p < 001. ROC analyses indicated comparable performance of perfusion and metabolism in the precuneus AUC, 0.72 and 0.74, IPL 0.85 and 0.94 for AD relative to FTD, and in the mPFC in FTD relative to AD both 0.68.

ConclusionsSimilar patterns of hypoperfusion and hypometabolism were observed in regions typically associated with AD and FTD, suggesting that ASL-MRI provides information comparable to FDG-PET.

Key Points• Similar patterns of hypoperfusion and hypometabolism were observed in patients with dementia.

• For both imaging modalities, parietal abnormalities were found in Alzheimer’s disease.

• For both imaging modalities, prefrontal abnormalities were found in frontotemporal dementia.

KeywordsPerfusion MRI Positron-emission tomography F-FDG Alzheimer’s disease Frontotemporal dementia All authors are affiliated with the Neuroscience Campus Amsterdam and VU University Medical Centre

Electronic supplementary materialThe online version of this article doi:10.1007-s00330-015-3696-1 contains supplementary material, which is available to authorized users.

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Author: Sander C. J. Verfaillie - Sofie M. Adriaanse - Maja A. A. Binnewijzend - Marije R. Benedictus - Rik Ossenkoppele - Mike

Source: https://link.springer.com/



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