Differential response in levels of high-density lipoprotein cholesterol to one-year metformin treatment in prediabetic patients by race-ethnicityReport as inadecuate




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Cardiovascular Diabetology

, 14:79

First Online: 12 June 2015Received: 22 April 2015Accepted: 03 June 2015

Abstract

BackgroundAs a first-line diabetes drug that is widely prescribed around the world, metformin has been demonstrated to be effective in reducing microvascular risk, in addition to lowering glucose levels. Specifically, metformin use has been shown to be associated with improved lipid profiles, such as increased levels of high-density lipoprotein cholesterol HDL-C. However, no study has been performed to examine the differential response in HDL-C levels to metformin treatment by race-ethnicity.

MethodsHere, based on a re-analysis of the data from the Diabetes Prevention Program, which involved pre-diabetic participants receiving 850 mg of metformin twice daily, we compared the lipid profile changes following the metformin use. The participants were composed of 602 Whites, 221 African Americans AAs and 162 Hispanics.

ResultsWe found that the one-year metformin treatment resulted in a significant increase in HDL-C levels in Whites p = 0.002 and AAs p = 0.016, but not in Hispanics. Consistently, both Whites p = 0.018 and AAs p = 0.020 had more pronounced changes in HDL-C levels than Hispanics following metformin treatment.

ConclusionThis result suggests a notion that Whites and AAs are more responsive than Hispanics to one-year metformin use in HDL-C level changes, and that racial and ethnic identity is a factor to consider when interpreting the effects of metformin treatment on lipid profiles.

KeywordsCholesterol Diabetes HDL Metformin AbbreviationsAAAfrican American

CHOLCholesterol

DPPDiabetes Prevention Program

GEEGeneralized estimating equation

LDLLow density lipoprotein cholesterol

HDL-CHigh density lipoprotein cholesterol

LDLBLDL-B sub-fraction

LDLCLDL-C sub-fraction

LDLZLDL particle size

TRIGTriglycerides

VLDLVery low density lipoprotein cholesterol

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Author: Chao Zhang - Feng Gao - Hao Luo - Chun-Ting Zhang - Ren Zhang

Source: https://link.springer.com/article/10.1186/s12933-015-0240-1



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