High-risk type-2 diabetes mellitus patients, without prior ischemic events, have normal blood platelet functionality profiles: a cross-sectional studyReport as inadecuate




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Cardiovascular Diabetology

, 14:80

First Online: 12 June 2015Received: 21 April 2015Accepted: 06 June 2015

Abstract

BackgroundPatients with type 2 diabetes mellitus DM display a predisposition for vascular disease. Platelets taken from vasculopathic diabetic patients, show enhanced stimuli-induced activation and aggregation responses. Aspirin remains the cornerstone antiplatelet agent for secondary prevention of vascular complications among diabetic patients, yet evidence of its efficacy and safety in primary prevention are conflicting. Our aim was to assess whether high risk diabetic patients, without previous ischemic events, have abnormal platelet functionality profiles.

MethodsThe study included 82 diabetic patients and 86 matched non-diabetic patients without prior ischemic events nor treatment with anti-platelet medications. Blood samples were analyzed for platelet markers of activation, turnover and leukocyte-platelet interactions.

ResultsOur final analysis included 122 males 74 %, with a mean age of 61 years. Mean platelet volume MPV was similar between the diabetic patients and controls 9.2 fL for both. Following activation, PAC-1 binding and P-selectin expression were found comparable between the diabetic patients and controls 83 % versus 81 % and 76 % versus 74 %, respectively. Leukocyte-platelet aggregates LPAs were similar between the diabetic patients and controls 18 % versus 17 %, respectively. Neutrophil-platelet aggregates NPAs and monocyte-platelet aggregates MPAs were also found similar in the diabetic patients and controls. Elevated fasting plasma glucose was associated with increased LPAs rates.

ConclusionsHigh risk type-2 diabetes mellitus patients, without prior ischemic events, have normal blood platelet functionality profiles.

KeywordsDiabetes mellitus Platelets activity Primary prevention Cardiovascular risk Aspirin Gadi Shlomai and Tal Haran-Appel contributed equally to this work.

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Author: Gadi Shlomai - Tal Haran-Appel - Tal Sella - Yoni Grossman - Hagit Hauschner - Nurit Rosenberg - Ehud Grossman

Source: https://link.springer.com/article/10.1186/s12933-015-0244-x







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