A prospective, double-blind, randomized controlled trial of treatment of atlantoaxial instability with C1 posterior arches >4 mm by comparing C1 pedicle with lateral mass screws fixationReport as inadecuate




A prospective, double-blind, randomized controlled trial of treatment of atlantoaxial instability with C1 posterior arches >4 mm by comparing C1 pedicle with lateral mass screws fixation - Download this document for free, or read online. Document in PDF available to download.

BMC Musculoskeletal Disorders

, 17:164

Orthopedics and biomechanics

Abstract

BackgroundC1 posterior arch screw placement is one of the most effective treatments for atlantoaxial instability AAI, which can be performed by either pedicle or lateral mass screw fixation. This study attempted to compare the feasibility and clinical outcomes of C1 pedicle with lateral mass screw fixations for treatment of AAI with C1 posterior arches >4 mm.

MethodsA total of 140 patients with AAI C1 posterior arches measuring >4 mm was enrolled in this single-center, randomized, double-blind trial. The subjects were randomly assigned into two treatments: C1 pedicle group A or lateral mass group B screw fixation. The patients, independent evaluating physicians and radiologists were blinded throughout the entire study. Patients were assessed before operation and in a series of follow-ups at 6 weeks, 6 months, 1 year, and 3 years post-surgery. The operation time, volume of blood loss, intraoperative complications, bone fusion rates, Japanese Orthopaedic Association JOA and visual analog scale VAS scores were monitored.

ResultsAll 140 patients showed overall improvements in clinical symptoms after surgery. The mean follow-up time was 24.5 ± 13.0 months. In both groups, the mean JOA scores improved significantly at the time of final follow-up as compared to prior surgery group A: 7.1 ± 1.4 vs 13.7 ± 1.9; group B:7.3 ± 1.8 vs 13.1 ± 1.4; improvement rates: 87.2 % group A and 86.5 % group B. The VAS scores also decreased significantly in both groups at the time of final follow-up as compared to prior surgery group A: 6.0 ± 1.3 vs 1.7 ± 0.8, and group B: 5.7 ± 1.1 vs 2.1 ± 1.2. Bone fusion was achieved within 12 months postoperatively in the patients from both groups. The operation time was significantly shorter and volume of blood loss was significantly less in the patients from group A as compared to group B p < 0.01. Furthermore, thirteen patients had burst bleeding from the C1-2 venous plexus and nine patients had immediate pain and numbness in the occipitocervical region due to C2 nerve roots irritation during lateral mass screw replacement, which were not observed in the patients with C1 pedicle screw insertion. No complications such as screw loosening, shifting, breakage, or AAI were observed in both groups.

ConclusionsC1 pedicle screw fixation is less invasive and simpler, and has fewer complications. It renders better clinical outcomes than lateral mass screw fixation for treatment of AAI.

Trial registrationCurrent Controlled Trials ChiCTR-IOR-15006748.

KeywordsAtlantoaxial instability C1 Lateral mass Pedicle Complications Dr. Liang Yan and Dr. Baorong He considered as co-first authors.

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Author: Liang Yan - Baorong He - Tuanjiang Liu - Lixue Yang - Dingjun Hao

Source: https://link.springer.com/







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