HLA II class alleles in juvenile idiopathic arthritis patients with and without temporomandibular joint arthritisReport as inadecuate




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Pediatric Rheumatology

, 14:24

First Online: 19 April 2016Received: 05 October 2015Accepted: 14 April 2016

Abstract

BackgroundTemporomandibular joint TMJ arthritis is seen very often 38–87 % in children with juvenile idiopathic arthritis JIA. With contrast enhanced magnetic resonance imaging MRI we can detect more cases of TMJ arthritis than ever before. Previous studies show that HLA II class alleles may have protective or risk importance in JIA subtypes. Our objective is to identify HLA II class alleles of risk and protection in JIA patients with TMJ arthritis.

MethodsDuring the period from 2010 to 2015 MRI for TMJ was performed in 85 JIA patients who were genotyped for HLA- DRB1; DQB1 and DQA1 using RT-PCR with sequence-specific primers. As a control group, data of 100 individuals were taken from the genetic bank of RSU Joint Laboratory of Clinical Immunology and Immunogenetics. Associations of DRB1; DQB1; DQA1 alleles in patients were examined individually using the χ test. P-value <0.05 and odds ratio were calculated using EPI INFO 6.0 software.

ResultsOut of 85 JIA patients with mean age of 13.7 ± 3.0 years range 6.9–17.9 years, 59 69 % were girls and 26 31 % were boys. The mean duration of the disease was 3.07 ± 2.35 years range 0.2–11.0 year. JIA subtypes were as follows: seronegative polyarthritis 51 60 %, seropositive polyarthritis 67 %, oligoarthritis extended 78 %, oligoarthritis persistent 2 2 % arthritis with enthesitis 14 17 %, undifferentiated 3 4 % and 2 2 % systemic arthritis. Two groups where separated after TMJ MRI exam: first with at least two signs of active inflammation and-or any structural damage n = 62; second with no pathologic signs or with slight contrast enhancement n = 23. We discovered that there are risk alleles that are found in all JIA patient’s groups MRI positive and negative groups versus controls such as DRB1*07:01, DQB1*03:03; DQB1*05:01. Also some protective alleles as DRB1*18:01, DQB1*06:02–8 were found in overall JIA group. Alleles DRB1*12:01, DQB1*03:01; DQA1*05:01 were found to be protective for TMJ arthrits.

ConclusionIn our study there were no convincing risk alleles, but there are alleles that probably are protective for TMJ arthritis like DRB1*12:01, DQB1*03:01; DQA1*05:01.

KeywordsTemporomandibular joint arthritis Juvenile idiopathic arthritis HLA II class alleles AbbreviationsACRAmerican College of Rheumatology

ANAantinuclear antibodies

CRPC-reactive protein

ESRerythrocyte sedimentation rate

HLAhuman leukocyte antigens

ILARInternational League of Associations for Rheumatology

IQRinterquartile range

JIAjuvenile idiopathic arthritis

MRImagnetic resonance imaging

PTPN22protein tyrosine phosphatase, non-receptor type 2

RFrheumatoid factor

RSURiga Stradiņš University

RT-PCRreal time polimerase chain reaction

SDstandard deviation

TMJtemporomandibular joint

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