Expression of MHC Class II Antigens During Xenopus DevelopmentReport as inadecuate




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Developmental Immunology - Volume 1 1990, Issue 2, Pages 85-95



Basel Institute for Immunology, Grenzacherstrasse 487, Basel CH-4058, Switzerland

Department of Microbiology and Immunology, University of Miami, P.O. Box 01690, Miami 33101, Florida, USA

Received 25 April 1990; Accepted 3 May 1990

Copyright © 1990 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Larval and adult forms of the amphibian Xenopus differ in their MHC class II .expression. Intadpoles, class II epitopes can be detected by monoclonal antibodies only on B cells, macrophageswhatever their location, spleen reticulum, thymus epithelium, and the pharyngobuccalcavity. In contrast, all adult T cells express class II on their surface. The transitions inclass II expression occur at metamorphosis and are accompanied by other changes. The skinis invaded by class II positive dendritic cells, and the skin glands differentiate and alsoexpress class II. The gut, which expressed class II in discrete areas of the embryonic tissue,becomes invaded with B cells, and its epithelium also becomes class II positive.





Author: Louis Du Pasquier and Martin F. Flajnik

Source: https://www.hindawi.com/



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