The effect of etanercept on traditional metabolic risk factors for cardiovascular disease in patients with rheumatoid arthritisReport as inadecuate




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Clinical Rheumatology

, Volume 35, Issue 12, pp 3045–3052

First Online: 05 October 2016Received: 15 June 2016Revised: 14 September 2016Accepted: 17 September 2016

Abstract

Patients with rheumatoid arthritis RA are at an increased risk of cardiovascular disease CVD. Treatment with tumor necrosis factor inhibitors improves both joint symptoms associated with RA and also CVD risk. This exploratory analysis of a phase 4 study evaluated changes in metabolic risk factors in patients with RA treated with etanercept. Metabolic analytes were measured at baseline, week 12, and week 24 in patients enrolled in a randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of etanercept in moderately active RA. Patients received either placebo or etanercept 50 mg every week QW for 12 weeks, after which all patients received etanercept 50 mg QW through week 24. Levels of metabolic analytes were assessed in all patients, including patients with diabetes and hyperlipidemia, and described descriptively. A total of 210 patients were randomized, 104 to placebo and 106 to etanercept. There were no significant changes in metabolic risk factors from baseline to week 12 or 24 in all patients. Levels of metabolic analytes were similar in patients with diabetes and hyperlipidemia, with some exceptions; fasting glucose and fasting insulin decreased through week 12, and hemoglobin A1C decreased slightly through week 24 in patients with diabetes. Treatment with etanercept did not adversely affect levels of metabolic risk factors for CVD in patients with RA.

KeywordsCardiovascular disease Rheumatoid arthritis Tumor necrosis factor inhibitor  Download fulltext PDF



Author: Atul Deodhar - Bojena Bitman - Yue Yang - David H Collier

Source: https://link.springer.com/



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