Safety and Efficacy of Stereotactic Body Radiation Therapy in the Treatment of Pulmonary Metastases from High Grade SarcomaReport as inadecuate




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SarcomaVolume 2013 2013, Article ID 360214, 6 pages

Clinical Study

Department of Radiation Oncology, David Geffen School of Medicine at UCLA, 200 UCLA Medical Plaza, B265, Los Angeles, CA 90095, USA

UCLA Jonsson Comprehensive Cancer Center, 10833 Le Conte Ave, Los Angeles, CA 90095, USA

Division of Pediatric Hematology Oncology, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA

Division of Thoracic Surgery, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA

Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA

Division of Hematology Oncology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA

Received 8 May 2013; Revised 7 August 2013; Accepted 30 August 2013

Academic Editor: Cyril Fisher

Copyright © 2013 Niraj Mehta et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. Patients with high-grade sarcoma HGS frequently develop metastatic disease thus limiting their long-term survival. Lung metastases LM have historically been treated with surgical resection metastasectomy. A potential alternative for controlling LM could be stereotactic body radiation therapy SBRT. We evaluated the outcomes from our institutional experience utilizing SBRT. Methods. Sixteen consecutive patients with LM from HGS were treated with SBRT between 2009 and 2011. Routine radiographic and clinical follow-up was performed. Local failure was defined as CT progression on 2 consecutive scans or growth after initial shrinkage. Radiation pneumonitis and radiation esophagitis were scored using Common Toxicity Criteria CTC version 3.0. Results. All 16 patients received chemotherapy, and a subset 38% also underwent prior pulmonary metastasectomy. Median patient age was 56 12–85, and median follow-up time was 20 months range 3–43. A total of 25 lesions were treated and evaluable for this analysis. Most common histologies were leiomyosarcoma 28%, synovial sarcoma 20%, and osteosarcoma 16%. Median SBRT prescription dose was 54 Gy 36–54 in 3-4 fractions. At 43 months, local control was 94%. No patient experienced G2-4 radiation pneumonitis, and no patient experienced radiation esophagitis. Conclusions. Our retrospective experience suggests that SBRT for LM from HGS provides excellent local control and minimal toxicity.





Author: Niraj Mehta, Michael Selch, Pin-Chieh Wang, Noah Federman, Jay M. Lee, Fritz C. Eilber, Bartosz Chmielowski, Nzhde Agazarya

Source: https://www.hindawi.com/



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