Association of Platelet to lymphocyte ratio with non-culprit atherosclerotic plaque vulnerability in patients with acute coronary syndrome: an optical coherence tomography studyReport as inadecuate




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BMC Cardiovascular Disorders

, 17:175

Coronary artery disease

Abstract

BackgroundThe platelet to lymphocyte ratio PLR, an indirect inflammatory biomarker, has been recently demonstrated to be associated with severity of coronary artery disease. In the present study, we sought to investigate whether PLR is associated with vulnerable plaque characteristics of non-culprit lesions in patients with acute coronary syndrome ACS.

MethodsThe patients in our study were divided into two groups high PLR group and low PLR group. A total of 119 non-culprit plaques from 71 patients with ACS were assessed by optical coherence tomography OCT.

ResultsThe non-culprit plaques in high PLR group exhibited thinner fibrous cap thickness FCT 88.60 ± 44.70 vs. 119.28 ± 50.22 μm, P = 0.001, greater maximum lipid arc 271.73 ± 71.66 vs. 240.60 ± 76.69°, P = 0.027 and increased incidence of thin-cap fibroatheroma TCFA 34.0% vs. 15.9%, P = 0.022 compared with those in low PLR group. Meanwhile, PLR was negatively associated with FCT r = −0.329, P < 0.001. Furthermore, multivariate regression analysis showed that PLR OR: 1.023 95% CI: 1.005–1.041, P = 0.012 and LDL-C OR: 1.892 95% CI: 1.106–3.239, P = 0.020 were significant predictors of TCFA.

ConclusionsHigh level of PLR may be associated with vulnerable plaque features of non-culprit lesions in patients with ACS. PLR, a cheap and easily available index, may surve as a useful inflammatory marker in reflecting plaque vulnerability.

KeywordsPlatelet to lymphocyte ratio Atherosclerosis Plaque vulnerability Optical coherence tomography AbbreviationsACSAcute coronary syndrome

DSDiameter stenosis

FCTFibrous cap thickness

hs-CRPHigh sensitivity C-reacitve protein

IVUSIntravascular ultrasound

MLDMinimum lumen diameter

NLRNeutrophil-to-lymphocyte ratio

OCTOptical coherence tomography

PLRPlatelet to lymphocyte ratio

QCAQuantitative coronary angiography

RVDReference vessel diameter

STEMIST-segment elevated myocardial infarction

TCFAThin-cap fibroatheroma

UAPUnstable angina pectoris.

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Author: Xuedong Wang - Zulong Xie - Xinxin Liu - Xingtao Huang - Jiale Lin - Dan Huang - Bo Yu - Jingbo Hou

Source: https://link.springer.com/article/10.1186/s12872-017-0618-y



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