Dexpanthenol: An Overview of its Contribution to Symptom Relief in Acute Rhinitis Treated with Decongestant Nasal SpraysReport as inadecuate




Dexpanthenol: An Overview of its Contribution to Symptom Relief in Acute Rhinitis Treated with Decongestant Nasal Sprays - Download this document for free, or read online. Document in PDF available to download.

Advances in Therapy

pp 1–9

First Online: 10 July 2017Received: 16 March 2017

Abstract

Nasal blockage is the most bothersome symptom of acute rhinitis. Nasal decongestant sprays containing alpha-sympathomimetics, such as oxymetazoline and xylometazoline, have a rapid onset of action. However, this effect decreases with repeated application and, furthermore, the ciliary function of the nasal mucosa is practically paralyzed. Dexpanthenol promotes cell proliferation and protects the epithelium. Combining these two agents has demonstrated beneficial synergetic effects on the symptoms of acute rhinitis. In a post hoc analysis of a large-scale double-blind, active-controlled study including 152 patients, we could demonstrate that the benefit of added dexpanthenol appears as early as on the third day of the combined application of xylometazoline and dexpanthenol in terms of complete or near-to-complete freedom from symptoms. After 5 days, 47% of the patients were cured under the combined treatment compared with only 1% under xylometazoline monotherapy. These data show that the addition of dexpanthenol to an alpha-sympathomimetic nasal spray not only improves its tolerability but also further increases its effectiveness and leads to expedited cure.

Funding: Klosterfrau Healthcare Group.

KeywordsAcute rhinitis Allergy Dexpanthenol Nasal blockage Nasal decongestant spray Xylometazoline Enhanced contentTo view enhanced content for this article go to http:-www.medengine.com-Redeem-8BD8F0604A02ED5E.

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Author: Ralph Mösges - Kija Shah-Hosseini - Hans-Peter Hucke - Marie-Josefine Joisten

Source: https://link.springer.com/







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