Effects of AMPD1 gene C34T polymorphism on cardiac index, blood pressure and prognosis in patients with cardiovascular diseases: a meta-analysisReport as inadecuate




Effects of AMPD1 gene C34T polymorphism on cardiac index, blood pressure and prognosis in patients with cardiovascular diseases: a meta-analysis - Download this document for free, or read online. Document in PDF available to download.

BMC Cardiovascular Disorders

, 17:174

Hypertension and Cardiovascular Risk

Abstract

BackgroundThe meta-analysis was aimed to evaluate the effects of AMPD1 gene C34T polymorphism on cardiac function indexes, blood pressure and prognosis in patients with cardiovascular diseases CVD.

MethodsEligible studies were retrieved through a comprehensive search of electronic databases and manual search. Then the high-quality studies met the rigorous inclusion and exclusion criteria, as well as related to the subject was selected for the study. Comprehensive data analyses were conducted using STATA software 12.0.

ResultsThe study results revealed that CVD patients with CT + TT genotype of AMPD1 C34T polymorphism presented elevated left ventricular ejection fraction LVEF % and reduced left ventricular end diastolic dimension LVEDD mm as compared with CC genotype, moreover, the subgroup analysis found that the LVEF % was markedly higher in heart failure HF patients carrying CT + TT genotype than CC genotype. Besides, the systolic blood pressure SBP mmHg in CVD patients with CT + TT genotype was obviously decreased in contrast with the CC genotype. Patients suffered from HF with different genotypes CT + TT and CC of AMPD1 C34T polymorphism exhibited no significant differences in total survival rate and cardiac survival rate.

ConclusionsOur current meta-analysis indicated that the T allele of AMPD1 gene C34T polymorphism may be correlated with LVEF, LVEDD and SBP, which plays a protective role in the cardiac functions and blood pressure in CVD patients, but had no effects on total survival rate and cardiac survival rate for HF.

KeywordsAMPD1 Cardiovascular diseases C34T Polymorphism Cardiac indexes Blood pressure Prognosis AbbreviationsAMPD1adenosine monophosphate deaminase 1

CADcoronary artery diseases

CHFcongestive heart failure

CVDcardiovascular diseases

DBPdiastolic blood pressure

HFheart failure

LVEDDleft ventricular end diastolic dimension

LVEFleft ventricular ejection fraction

SBPsystolic blood pressure

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Author: Ai-Fang Feng - Zhong-Hui Liu - Shu-Long Zhou - Shi-Yuan Zhao - Yan-Xin Zhu - Huai-Xin Wang

Source: https://link.springer.com/article/10.1186/s12872-017-0608-0







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