Lutein Has a Protective Effect on Hepatotoxicity Induced by Arsenic via Nrf2 SignalingReport as inadecuate




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BioMed Research International - Volume 2015 2015, Article ID 315205, 10 pages -

Research Article

Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China

Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi, Xinjiang 832002, China

Department of Science and Technology, The Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi 830011, China

Department of Pathology, The Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi 830011, China

Received 31 October 2014; Revised 24 December 2014; Accepted 24 December 2014

Academic Editor: Chetna Singh

Copyright © 2015 Shugang Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Arsenic produces liver disease through the oxidative stress. While lutein can alleviate cytotoxic and oxidative injury, nuclear factor erythroid 2-related factor 2 Nrf2 pathway plays a critical role in defending oxidative species. However, the mechanisms by which lutein protects the liver against the effect of arsenic are not known. Therefore, this study aims to investigate the mechanisms involved in the action of lutein using mice model in which hepatotoxicity was induced by arsenic. We found that mice treatment with lutein could reverse changes in morphological and liver indexes and result in a significant improvement in hepatic function comparing with arsenic trioxide group. Lutein treatment improved the activities of antioxidant enzymes and attenuated increasing of ROS and MDA induced by arsenic trioxide. Lutein could increase the mRNA and protein expression of Nrf2 signaling related genes Nrf2, Nqo1, Ho-1, and Gst. These findings provide additional evidence that lutein may be useful for reducing reproductive injury associated with oxidative stress by the activation of Nrf2 signaling. Our findings suggest a possible mechanism of antioxidant lutein in preventing the hepatotoxicity, which implicate that a dietary lutein may be a potential treatment for liver diseases, especially for arsenicosis therapy.





Author: Shugang Li, Yusong Ding, Qiang Niu, Shangzhi Xu, Lijuan Pang, Rulin Ma, Mingxia Jing, Gangling Feng, Jing Xia Tang, Qian

Source: https://www.hindawi.com/



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