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Journal of PregnancyVolume 2012 2012, Article ID 315203, 9 pages

Review Article

Department of Pediatrics, McMaster University, 1200 Main Street West, Room 3N11, Hamilton, ON, Canada L8N 3Z5

Department of Psychiatry, Women-s College Research Institute, University of Toronto, Toronto, ON, Canada M5S 1B1

Department of Obstetrics and Gynecology, McMaster University, 1200 Main Street West, Room 3N52, Hamilton, ON, Canada L8N 3Z5

Received 3 April 2012; Accepted 18 June 2012

Academic Editor: Timothy Regnault

Copyright © 2012 Sandeep Raha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

There is currently considerable uncertainty regarding prescribing practices for pregnant women with severe and persistent psychiatric disorders. The physician and the mother have to balance the risks of untreated psychiatric illness against the potential fetal toxicity associated with pharmacological exposure. This is especially true for women taking atypical antipsychotics. Although these drugs have limited evidence for teratological risk, there are reports of altered fetal growth, both increased and decreased, with maternal atypical antipsychotic use. These effects may be mediated through changes in the maternal metabolism which in turn impacts placental function. However, the presence of receptors targeted by atypical antipsychotics in cell lineages present in the placenta suggests that these drugs can also have direct effects on placental function and development. The signaling pathways involved in linking the effects of atypical antipsychotics to placental dysfunction, ultimately resulting in altered fetal growth, remain elusive. This paper focuses on some possible pathways which may link atypical antipsychotics to placental dysfunction.





Author: Sandeep Raha, Valerie H. Taylor, and Alison C. Holloway

Source: https://www.hindawi.com/



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