Helicobacter pylori and the Prevention of Gastric CancerReport as inadecuate




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Canadian Journal of Gastroenterology - Volume 18 2004, Issue 5, Pages 295-302

Review

Division of Research and Cancer Control, Cancer Care Ontario, Toronto, Ontario, Canada

Department of Health Policy, Management and Evaluation, and Department of Public Health Science, University of Toronto, Toronto, Ontario, Canada

Department of Oncology, McGill University, Montreal, Quebec, Canada

PICEPS Consultants Inc, Whitby, Ontario, Canada

Division of Gastroenterology, McGill University, Montreal, Quebec, Canada

Schabas & Associates, Toronto, Ontario, Canada

Department of Family Medicine, University of Toronto, Toronto, Ontario, Canada

Clinical Ethics Centre, Sunnybrook and Women’s College Health Sciences Centre, Toronto, Ontario, Canada

Department of Gastroenterology, McMaster University Medical Centre, Hamilton, Ontario, Canada

Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada

Departments of Pediatrics and Physiology, University of Toronto, Toronto, Ontario, Canada

Received 9 September 2003; Accepted 19 March 2004

Copyright © 2004 Hindawi Publishing Corporation. This open-access article is distributed under the terms of the Creative Commons Attribution Non-Commercial License CC BY-NC http:-creativecommons.org-licenses-by-nc-4.0-, which permits reuse, distribution and reproduction of the article, provided that the original work is properly cited and the reuse is restricted to noncommercial purposes.

Abstract

BACKGROUND: Helicobacter pylori is an important cause of stomach cancer that infects a substantial proportion of the Canadian adult population. H pylori can be detected by noninvasive tests and effectively eradicated by medical treatment. Screening for and treatment of H pylori may represent a significant opportunity for preventive oncology.

METHODS: Cancer Care Ontario organized a workshop held in Toronto, Ontario, on October 24 and 25, 2002, to: review the current state of knowledge regarding H pylori treatment and cancer prevention; determine if there is currently sufficient evidence to consider the promotion of H pylori treatment for the purpose of cancer prevention; identify critical areas for research; and advise Cancer Care Ontario on H pylori and cancer prevention.

RESULTS: Workshop participants developed a number of recommendations for research into the relationship between H pylori and stomach cancer, including determining the prevalence of infection in different regions of Canada, the pathogenetic sequence of carcinogenesis from H pylori infection, and the implementation of a prospective observational study.

INTERPRETATION: Although the rate of H pylori infection is declining in Canada and the treatment of H pylori is generally accepted to be safe, the evidence to date may not warrant the implementation of population screening for H pylori infection to prevent gastric carcinoma in average-risk populations. Rather, a demonstration project is needed to estimate prevalence, evaluate the merits of screening, measure patient compliance and physician participation, develop education materials, establish a registry for monitoring and evaluation, and develop a quality assurance framework.





Author: Terrence Sullivan, Fredrick D Ashbury, Carlo A Fallone, Farah Naja, Richard Schabas, Philip C Hébert, Richard Hunt, and Nicola J

Source: https://www.hindawi.com/



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