Genome Alteration Print GAP: a tool to visualize and mine complex cancer genomic profiles obtained by SNP arrays.Report as inadecuate




Genome Alteration Print GAP: a tool to visualize and mine complex cancer genomic profiles obtained by SNP arrays. - Download this document for free, or read online. Document in PDF available to download.

* Corresponding author 1 Unité de génétique et biologie des cancers 2 Département de Biologie des Tumeurs 3 MIA-Paris - Mathématiques et Informatique Appliquées 4 Département de recherche translationnelle 5 Cancer et génôme: Bioinformatique, biostatistiques et épidémiologie d-un système complexe

Abstract : We describe a method for automatic detection of absolute segmental copy numbers and genotype status in complex cancer genome profiles measured with single-nucleotide polymorphism SNP arrays. The method is based on pattern recognition of segmented and smoothed copy number and allelic imbalance profiles. Assignments were verified by DNA indexes of primary tumors and karyotypes of cell lines. The method performs well even for poor-quality data, low tumor content, and highly rearranged tumor genomes.





Author: Tatiana Popova - Elodie Manié - Dominique Stoppa-Lyonnet - Guillem Rigaill - Emmanuel Barillot - Marc Stern -

Source: https://hal.archives-ouvertes.fr/



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