Evaluation of Stability and In Vitro Security of Nanoemulsions Containing Eucalyptus globulus OilReport as inadecuate




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BioMed Research International - Volume 2017 2017, Article ID 2723418, 10 pages - https:-doi.org-10.1155-2017-2723418

Research Article

Curso de Biomedicina, Centro Universitário Franciscano, Santa Maria, RS, Brazil

Programa de Pós-Graduação em Nanociências, Centro Universitário Franciscano, Santa Maria, RS, Brazil

Laboratório Escola de Análises Clínicas, Centro Universitário Franciscano, Santa Maria, RS, Brazil

Departamento de Tecnologia e Ciência dos Alimentos, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil

Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil

Correspondence should be addressed to Aline Ferreira Ourique

Received 29 December 2016; Accepted 14 May 2017; Published 11 June 2017

Academic Editor: Maqusood Ahamed

Copyright © 2017 Samantha Nunes de Godoi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Essential oil of Eucalyptus globulus presents several pharmacological properties. However, their therapeutic efficacy may be affected by limitations due to several conditions, rendering it difficult to obtain stable and effective pharmaceutical formulations. The use of nanotechnology is an alternative to improve their characteristics aiming to ensure their stability and effectiveness. Furthermore, studies about the possible toxic effects of nanostructures are necessary to evaluate safety when the formulation comes into contact with human cells. Hence, in this paper, we evaluate for the first time the stability and in vitro cytogenotoxicity of nanoemulsions containing Eucalyptus globulus in peripheral blood mononuclear cells. As a result, the stability study found that the best condition for storage up to 90 days was refrigeration 4°C; it was the condition that best preserved the nanometric features. The content of the major compounds of oil was maintained after nanoencapsulation and preserved over time. In tests to evaluate the safety of this formulation, we can conclude that, at a low concentration approximately 0.1%, Eucalyptus globulus nanoemulsion did not cause toxicity in peripheral blood mononuclear cells and also showed a protective effect in cells against possible damage when compared to oil in free form.





Author: Samantha Nunes de Godoi, Priscilla Maciel Quatrin, Michele Rorato Sagrillo, Kátia Nascimento, Roger Wagner, Bruna Klein, Ro

Source: https://www.hindawi.com/



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