Imaging of Acute Invasive Fungal Rhinosinusitis in a Patient with Gorlin Syndrome and Acute Lymphocytic LeukemiaReport as inadecuate




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Case Reports in OtolaryngologyVolume 2013 2013, Article ID 272314, 4 pages

Case Report

Department of Otolaryngology, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32608, USA

Department of Otolaryngology, University of Tennessee Health Sciences Center, 910 Madison Avenue, Memphis, TN 38163, USA

Department of Oncology, St. Jude Children’s Research Hospital, 262 Danny Thomas Boulevard, MS-260, Memphis, TN 38105, USA

Department of Infectious Diseases, St. Jude Children’s Research Hospital, 262 Danny Thomas Boulevard, MS-320, Memphis, TN 38105, USA

Departments of Pediatrics and Ophthalmology, University of Tennessee Health Sciences Center, 711 Jefferson Avenue, Suite 523, Memphis, TN 38105, USA

Department of Radiological Sciences, St. Jude Children’s Research Hospital, 262 Danny Thomas Boulevard, MS-220, Memphis, TN 38105, USA

Received 19 March 2013; Accepted 8 May 2013

Academic Editors: V. A. Resto and H. Sudhoff

Copyright © 2013 S. T. Donovan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Gorlin Syndrome GS, also known as nevoid basal cell carcinoma syndrome, is a rare autosomal dominant condition characterized by developmental abnormalities and predisposition to certain neoplasms. Acute invasive fungal rhinosinusitis AIFRS is an uncommon clinical entity characterized by high morbidity and mortality. In immunocompromised patients, computed tomography plays a critical role in screening for suspected AIFRS. However, due to the association between exposure to ionizing radiation and subsequent development of malignancies in patients with GS, patients with GS and suspected AIFRS present a unique and challenging clinical scenario. We present a case of a pediatric patient with GS and acute lymphocytic leukemia ALL diagnosed with AIFRS; to the best of our knowledge, it is the only case described in the literature.





Author: S. T. Donovan, J. W. Thompson, J. T. Sandlund, E. E. Adderson, E. K. Pivnick, and J. H. Harreld

Source: https://www.hindawi.com/



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