Successful Use of Posaconazole to Treat Invasive Cutaneous Fungal Infection in a Liver Transplant Patient on SirolimusReport as inadecuate




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Canadian Journal of Infectious Diseases and Medical Microbiology - Volume 23 2012, Issue 2, Pages e44-e47

Case Report

Department of Internal Medicine, McMaster University, Canada

Division of General Internal Medicine, Hamilton Health Sciences, Hamilton, Ontario, Canada

Division of Infectious Diseases, Hamilton Health Sciences, Hamilton, Ontario, Canada



Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Fungi are an important and common cause of cutaneous infections affecting solid organ transplant recipients. These infections can represent a primary site of infection with the potential for dissemination, or a manifestation of metastatic infection. The high morbidity and mortality associated with these infections necessitates urgent therapy with antifungal drugs; however, the interaction between these drugs and immunosuppressive therapies can be a major limitation because of drug toxicity. A case of soft tissue infection of the toe caused by Fusarium chlamydosporum and Candida guilliermondii in a liver transplant patient on sirolimus, who was successfully treated with the new antifungal agent posaconazole, is described. The pharmacokinetic interactions of sirolimus and the new triazoles, and their impact on treatment choices are briefly discussed.





Author: Randah Dahlan, Ameen Patel, and Shariq Haider

Source: https://www.hindawi.com/



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