Electrochemical Oxidation of an Immunosuppressant, Mycophenolate Mofetil, and Its Assay in Pharmaceutical FormulationsReport as inadecuate




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International Journal of ElectrochemistryVolume 2011 2011, Article ID 193041, 7 pages

Research Article

Department of Chemistry, Karnatak University, Dharwad 580 003, India

Department of Chemistry, SJM College, Chitradurga 577 501, India

Received 9 June 2011; Revised 21 July 2011; Accepted 1 August 2011

Academic Editor: Emmanuel Maisonhaute

Copyright © 2011 S. N. Prashanth et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Electrochemical oxidation of mycophenolate mofetil MMF has been studied at a glassy carbon electrode in aqueous solution over a wide pH range. MMF was oxidized on glassy carbon electrode GCE by an irreversible process that was controlled mainly by diffusion. The irreversibility of the electrode process was verified by different criteria. A probable mechanism for electrochemical oxidation of MMF was proposed. Differential-pulse voltammogram of the drug showed two oxidation peaks at 0.631 V and at 0.921 V verses SCE in phosphate buffer of pH 6.0. This process could be used to determine MMF in the concentration range of to  M with a limit of detection of  M. The method was successfully applied for the analysis of MMF in pure and dosage forms and in biological fluids.





Author: S. N. Prashanth, K. C. Ramesh, and J. Seetharamappa

Source: https://www.hindawi.com/



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